chemical reaction
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- Food and Agriculture Organisation of the United Nations - Fermented Foods: An Ancient Tradition
- Open Oregon Educational Resources - Mt Hood Community College Biology 101 - Fermentation: An Anaerobic Process
- University of Minnesota Libraries - Vet Med: Applied GI Physiology - Supplemental Notes - Fermentation
- National Center for Biotechnology Information - PubMed Central - The Role of Yeasts in Fermentation Processes
- WebMD - What Is Food Fermentation?
- BCcampus Open Publishing - Concepts of Biology – 1st Canadian Edition - Fermentation
- Nature - Yeast Fermentation and the Making of Beer and Wine
- Biology LibreTexts - Fermentation
- Khan Academy - Fermentation and Anaerobic Respiration
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- fermentation - Children's Encyclopedia (Ages 8-11)
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- Food and Agriculture Organisation of the United Nations - Fermented Foods: An Ancient Tradition
- Open Oregon Educational Resources - Mt Hood Community College Biology 101 - Fermentation: An Anaerobic Process
- University of Minnesota Libraries - Vet Med: Applied GI Physiology - Supplemental Notes - Fermentation
- National Center for Biotechnology Information - PubMed Central - The Role of Yeasts in Fermentation Processes
- WebMD - What Is Food Fermentation?
- BCcampus Open Publishing - Concepts of Biology – 1st Canadian Edition - Fermentation
- Nature - Yeast Fermentation and the Making of Beer and Wine
- Biology LibreTexts - Fermentation
- Khan Academy - Fermentation and Anaerobic Respiration
Britannica Websites
Articles from Britannica Encyclopedias for elementary and high school students.
- fermentation - Children's Encyclopedia (Ages 8-11)
- fermentation - Student Encyclopedia (Ages 11 and up)
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Last Updated: •Article History
- Key People:
- Louis Pasteur
- Hans von Euler-Chelpin
- Sir Arthur Harden
- Eduard Buchner
- Related Topics:
- industrial fermentation
- cap
- bottle fermentation
- bottom fermentation
- malolactic fermentation
See all related content →
fermentation, chemical process by which molecules such as glucose are broken down anaerobically. More broadly, fermentation is the foaming that occurs during the manufacture of wine and beer, a process at least 10,000 years old. The frothing results from the evolution of carbon dioxide gas, though this was not recognized until the 17th century. French chemist and microbiologist Louis Pasteur in the 19th century used the term fermentation in a narrow sense to describe the changes brought about by yeasts and other microorganisms growing in the absence of air (anaerobically); he also recognized that ethyl alcohol and carbon dioxide are not the only products of fermentation.
Anaerobic breakdown of molecules
In the 1920s it was discovered that, in the absence of air, extracts of muscle catalyze the formation of lactate from glucose and that the same intermediate compounds formed in the fermentation of grain are produced by muscle. An important generalization thus emerged: that fermentation reactions are not peculiar to the action of yeast but also occur in many other instances of glucose utilization.
Glycolysis, the breakdown of sugar, was originally defined about 1930 as the metabolism of sugar into lactate. It can be further defined as that form of fermentation, characteristic of cells in general, in which the six-carbon sugar glucose is broken down into two molecules of the three-carbon organic acid, pyruvic acid (the nonionized form of pyruvate), coupled with the transfer of chemical energy to the synthesis of adenosine triphosphate (ATP). The pyruvate may then be oxidized, in the presence of oxygen, through the tricarboxylic acid cycle, or in the absence of oxygen, be reduced to lactic acid, alcohol, or other products. The sequence from glucose to pyruvate is often called the Embden–Meyerhof pathway, named after two German biochemists who in the late 1920s and ’30s postulated and analyzed experimentally the critical steps in that series of reactions.
Britannica QuizTypes of Chemical ReactionsThe term fermentation now denotes the enzyme-catalyzed, energy-yielding pathway in cells involving the anaerobic breakdown of molecules such as glucose. In most cells the enzymes occur in the soluble portion of the cytoplasm. The reactions leading to the formation of ATP and pyruvate thus are common to sugar transformation in muscle, yeasts, some bacteria, and plants.
Industrial fermentation
Industrial fermentation processes begin with suitable microorganisms and specified conditions, such as careful adjustment of nutrient concentration. The products are of many types: alcohol, glycerol, and carbon dioxide from yeast fermentation of various sugars; butyl alcohol, acetone, lactic acid, monosodium glutamate, and acetic acid from various bacteria; and citric acid, gluconic acid, and small amounts of antibiotics, vitamin B12, and riboflavin (vitamin B2) from mold fermentation. Ethyl alcohol produced via the fermentation of starch or sugar is an important source of liquid biofuel.
The Editors of Encyclopaedia BritannicaThis article was most recently revised and updated by Adam Augustyn.